20 Aug 2020 The main project, the antibody CAN04, is being studied in the clinical phase I/IIa CANFOUR study with a primary focus on non-small cell lung 

CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining combination with two different frequently used chemotherapy regimes in patients with non-small cell lung

Phase I In the CANFOUR part examining PDAC, 9 patients in the first cohort of 31 are currently on treatment with CAN04 in combination with gemcitabine and nab-paclitaxel. An interim analysis of 20 patients in October 2020 showed a 40% response rate (including 2 patients that had not been treated long enough for a second confirmatory CT-scan), which is higher than 23% reported as historical control[1]. Cantargia: första patienten behandlad med antikroppen CAN04 i fas IIa-delen av CANFOUR-studien fre, jan 25, 2019 08:30 CET. Cantargia AB (publ) meddelar idag att den första patienten i fas IIa-delen av den kliniska studien CANFOUR erhållit behandling med CAN04 (nidanilimab) i enlighet med det kliniska protokollet. Cantargia AB (publ) meddelar idag att den första patienten i fas IIa-delen av den kliniska studien CANFOUR erhållit behandling med CAN04 (nidanilimab) i enlighe Cantargia: Fas I säkerhetsutvärderingsdelen av CANFOUR studien med antikroppen CAN04 är genomförd och fas IIa-delen initieras fre, dec 07, 2018 15:30 CET. Cantargia AB (publ) meddelar idag att samtliga patienter i fas I-delen av den kliniska prövningen CANFOUR har fullföljt den formella säkerhetsutvärderingsdelen av studien. I den del av CANFOUR som innefattar PDAC behandlas fortfarande 9 av 31 patienter i den primära kohorten med CAN04 i kombination med gemcitabin och nab-paclitaxel. En interimsanalys av 20 patienter i oktober 2020 visade på s.k. respons i 40% av patienterna (inkluderande 2 patienter som inte behandlats tillräckligt länge för en andra, bekräftande CT-scan), vilket är högre än historiska CAN04 studeras för närvarande i en öppen trearmad fas I/IIa klinisk prövning, CANFOUR.

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Preliminära interimsdata som bolaget presenterade i december i Cantargia reports first patient treated in CANFOUR pancreatic cancer phase IIa extension cohort Wed, Feb 10, 2021 13:30 CET. Cantargia AB today announced that the first patient with pancreatic cancer (PDAC) has started treatment in the phase IIa extension part of the CANFOUR trial, investigating combination of CAN04 and chemotherapy. Cantargia AB (publ) meddelar idag att den första patienten i fas IIa-delen av den kliniska studien CANFOUR erhållit behandling med CAN04 (nidanilimab) i enlighet med det kliniska protokollet. I CANFOUR undersöks behandling med antikroppen CAN04 v Cantargia AB today announced that all 31 pancreatic cancer (PDAC) patients planned in the CANFOUR trial investigating combination of CAN04 and chemotherapy have started treatment. In the interim data set, no unexpected side effects have been reported, but notably fatigue and neuropathy were less common than reported from chemotherapy, while neutropenia was more common.

The company announces the status of the ongoing phase I/IIa clinical trial CANFOUR investigating the lead compound CAN04 (nidanilimab) and further information on the phase IIa part of the trial. So far, 15 patients have received therapy in the phase I safety part of the study, and generally the immuno-oncology antibody CAN04, targeting IL1RAP, has been well tolerated.

20 Aug 2020 The main project, the antibody CAN04, is being studied in the clinical phase I/IIa CANFOUR study with a primary focus on non-small cell lung 

CAN04 is investigated in phase IIa clinical development for non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC). Tumor samples from 15 patients

See Tweets about #canfour on Twitter. #Cantargia Reports Interim #Data from Phase 2A #CANFOUR Trial of CAN04 in #Pancreatic and #LungCancers 

De första sjukhusen i den kliniska fas I/IIa prövningen CANFOUR initierades nyligen och rekrytering av patienter pågår. I enlighet med protokollet behandlas patienterna i grupper om tre. The results from the CANFOUR study for Cantargia's candidate CAN04 are imminent, due in Q4 2019 and early 2020. The outcome will, in our view, represent a major valuation trigger for the share and potentially also lead to a partnership deal. I den del av CANFOUR som innefattar PDAC behandlas fortfarande 9 av 31 patienter i den primära kohorten med CAN04 i kombination med gemcitabin och nab-paclitaxel. En interimsanalys av 20 patienter i oktober 2020 visade på s.k. respons i 40% av patienterna (inkluderande 2 patienter som inte behandlats tillräckligt länge för en andra, bekräftande CT-scan), vilket är högre än historiska 2020-04-07 For the biopharma industry investment, business development and competitive intelligence professionals who require information to support financing, partnering and licensing activities, BCIQ provides accurate information and context to support profitable and strategic decision making.

CanFour är en Fas-1 studie med en ny läkemedel Can04. Can04 är en antikropp som har IL-1RAP som mål.
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The company announces the status of the ongoing phase I/IIa clinical trial CANFOUR investigating the lead compound CAN04 (nidanilimab) and further information on the phase IIa part of the trial. So far, 15 patients have received therapy in the phase I safety part of the study, and generally the immuno-oncology antibody CAN04, targeting IL1RAP, has been well tolerated. Styrelsen för Cantargia AB (publ) har, med stöd av bolagsstämmans bemyndigande, beslutat att genomföra en riktad nyemission om cirka 106 miljoner kronor. Likviden möjliggör en utökad satsning på bolagets huvudprojekt CAN04 (nidanilimab) med en ny klinisk studie i USA och en expansion av den mest lovande subgruppen patienter i den pågående kliniska studien CANFOUR. CAN04 är en Cantargia has provided updated interim data from its Phase IIa CANFOUR trial, reporting new efficacy data from the combination arms of the study investigating CAN04 (anti-IL1RAP) in first-line NSCLC and PDAC.

Cantargia´s antibody CAN04 (nidanilimab) is investigated in an open label three-armed phase IIa clinical trial, CANFOUR. Here, CAN04 is examined as monotherapy or in chemotherapy combinations in patients with non-small cell lung cancer (NSCLC) or pancreatic cancer (PDAC). CAN04 is investigated in a phase I/IIa clinical trial, CANFOUR, examining combination with two different, frequently used chemotherapy regimes in patients with NSCLC or pancreatic cancer (PDAC) in CANFOUR.
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The antibody CAN04 binds strongly to the target IL1RAP and functions both though ADCC as well as blocking IL-1α and IL-1β signaling. Thereby, CAN04 can counteract the contribution of the IL-1

The main project, the antibody CAN04, is being studied in the clinical phase I/IIa CANFOUR study with a primary focus on non-small cell lung cancer and pancreatic cancer. The study is focused on Cantargia is a clinical-stage biotechnology company based in Sweden, established in 2009 and listed on the Nasdaq Stockholm main market. It is developing two assets against IL1RAP, CAN04 and CAN10. CAN04 is being studied in a Phase IIa clinical trial, CANFOUR, in solid tumours focusing on NSCLC and pancreatic cancer. CAN04 is a humanized and antibody-dependent cellular cytotoxicity (ADCC)-enhanced IgG1 antibody targeting IL1RAP with two modes of action: blocking IL-1 alpha and beta signaling and triggering ADCC. This study included 22 patients with non–small cell lung cancer (NSCLC; four patients), pancreatic ductal adenocarcinoma (six patients), or The antibody CAN04 binds strongly to the target IL1RAP and functions both though ADCC as well as blocking IL-1α and IL-1β signaling.

Cantargia’s Phase IIa CANFOUR trial investigates CAN04 in a combination with a different chemotherapy (platinum-based as opposed to docetaxel in the Novartis trial) and CAN04 blocks the signalling from both IL-1alpha and IL-1beta (recent interim data from the CANFOUR trial was positive).

Det motiverade värdet höjs till 72 kronor från tidigare 39 kronor.

Thereby, CAN04 can counteract the contribution of the IL-1 CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining two different first line chemotherapy combinations in patients with non-small cell lung cancer or pancreatic cancer, as well as monotherapy in late stage patients. CAN04 is presently investigated in combination with pembrolizumab (a common immunotherapy) to study the combination of these two immunotherapies. The results in this trial together with those The phase IIa part is also expected to start in Q4 2018, investigating efficacy of CAN04 as both monotherapy as well as combination therapy in patients with non-small cell lung cancer (NSCLC) or pancreatic cancer. Results during Q4 2018 The first patient in the study started therapy in September 2017. Cantargia reports first patient treated in CANFOUR pancreatic cancer phase IIa extension cohort Wed, Feb 10, 2021 13:30 CET. Cantargia AB today announced that the first patient with pancreatic cancer (PDAC) has started treatment in the phase IIa extension part of the CANFOUR trial, investigating combination of CAN04 and chemotherapy.